artesunate相关论文
目的:比较青蒿琥酯(Art)和扶正化瘀方治疗血吸虫病肝纤维化对线粒体自噬的影响。方法:将80只C57BL/6雌性小鼠随机分为健康组、感染......
Investigation on the role and mechanisms of artesunate against Schistosoma japonicum induced liver f
Introduction The primary cause of death in Schistosomaiasis is the formation of liver egg granulomas and secondary hepat......
目的 The anti-malaria drug artesunate has been shown to attenuate experimental allergic asthma via inhibition of the pho......
Artesunate exhibits synergistic anti-cancer effects with cisplatin on lung cancer A549 cells by inhi
Objective Artesunate(ART)has been used extensively as anti-malarial drugs worldwide.Besids,it has also been reported to ......
Aim: Rhinovirus (RV)-induced asthma exacerbation has put a great burden on the healthcare management of asthmatics.The a......
Artesunate attenuated progression of atherosclerosis lesion formation alone or combined with rosuvas
Backgrounds:Inflammation plays an important role in all stages of atherosclerosis, but little is known about the therape......
The investigation of the turning point of over-inflammation to immunosuppression in CLP mice model a
Immunosuppression is the predominant cause of sepsis mortality.Due to the lack of effective treatments,investigations of......
ARTESUNATE DOWN-REGULATES IMMUNOSUPPRESSION FROM MURINE COLORECTAL TUMOR CELLS IN VITRO BY DECREASIN
Immunosuppression is the main source of ineffective treatment on tumor, and the study aimed to investigate the effect of......
Phosphate imbalance conducting by BPs-based cancer-targeting phosphate anions carrier induces necros
As a vital nutrient closely related to the cancer-cells proliferation, phosphate anions have been paid great attention a......
Calorie restriction(CR) promotes longevity among distinct organisms from yeast to mammals. Although CR-prolonged lifespa......
为了探讨青蒿琥酯(artesunate,ART)对糖尿病视网膜病变组织中抗凋亡和细胞保护作用相关因子Bcl-2和热休克蛋白27(Hsp27)表达的影响......
Objective To investigate the effects of artesunate(AS)on septic lung injury in mice and to study the modulation of heme ......
目的:为疟疾治疗制定基于聚合物的青蒿琥酯纳米粒。创新点:以聚乳酸羟乙酸共聚物(PLGA)为载体,制备青蒿琥酯纳米颗粒。并以小鼠为......
Reaction of a 1, 2, 4, 5-tetraoxane with cysteinate-iron in thepresence of excess methyl cysteinate led to formation of......
目的:在胃癌细胞系SGC-7901和HGC-27中探究青蒿琥酯的抗肿瘤效应并探讨其潜在的分子机制.方法:CCK-8实验检测不同浓度青蒿琥酯干预......
期刊
A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of
Recent evidence indicates that artesunate has immunomodulatory properties that might be useful for treating autoimmune d......
肝纤维化是各种慢性肝炎发展为肝硬化必经的病理阶段，同时也是向肝癌发展的中间环节。肝星状细胞（ HSC）是肝纤维化发生、发展的关键细......
目的 研究骨髓间充质干细胞(BMSCs)联合青蒿琥酯(Art)对肝纤维化大鼠模型的治疗效果.方法 120只SD大鼠,随机抽取20只作健康对照组,......
Enhanced lysosomal function is critical for paclitaxel resistance in cancer cells:reversed by artesu
The mechanism underlying the resistance of cancer cells to chemotherapeutic drug varies with different cancer cells.Rece......
Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths......
[目的 ]评价大规模应用青蒿琥酯预防性治疗接触疫水的人群预防血吸虫感染的效果。 [方法 ]在防汛中对 170 31人在接触疫水后第 7天......
目的 观察还原型谷胱甘肽 (GSH)对蒿甲醚伍用氯化血红素抗日本血吸虫作用的影响。 方法 将蒿甲醚、氯化血红素、GSH及谷胱甘肽......
有一种实验药物证明可抗击血吸虫病.血吸虫病是遍及热带地区的一种瘟疫,可感染几百万人.小鼠试验提示,该药物很可能作为当前所用的......
The efficacy of NP11-4-derived immunotoxin scFv-artesunate in reducing hepatic fibrosis inducedby Sc
Schistosomiasis is one of the most prevalent parasitic diseases in China,and hepatic fibrosis caused by schistosome infe......
Effect of artmether,hemin and Fe~(3+) on recombinant lactate dehydrogenase from Schistosoma japonicu
Objective:To explore antischitosome effects of artemether,hemin and Fe on S/LDH.Methods: Enzyme activity of rS/LDH was a......
<正>In a collective effort to find new drugs for killing the malaria parasites(plasmodium)that became resistant to the c......
Aim:To investigate the anticancer activity of dihydroartemisinin (DHA),a deriva-tive of antimalaria drug artemisinin in......
青蒿酯(artesunate)为双氢青蒿素的琥珀酸半酯,也是双氢青蒿素的前体药(pro-drug)。青蒿素是从中药黄花蒿Artemisia annua L.中分......
目的 探讨诺氏疟原虫 (Plasmodiumknowlesi)感染恒河猴 (Macacamulatta)引起有关脏器的病理组织学变化。方法 病解 3例感染疟原......
目的探讨青蒿琥酯(artesunate,Art)对人子宫内膜癌细胞血管生成素-2(angiopoietin-2,ang-2)基因表达及细胞增殖的影响。方法2007年......
This paper reports general and special to-xicological experiments on Qinghaosu and itsderivatives.Results point to the ......
麻醉犬静脉给予青蒿酯钠40mg、80mg/kg,对心泵功能、外周总阻力、血流动力学及心肌耗氧量;麻醉兔静脉给予青蒿酯钠,对心率、血压及......
Objective:To determine the suppressive and curative activity of aqueous leaf extract of Ageratum conyzoides(A.conyzoides......
Polymorphisms of the oxidant enzymes glutathione S-transferase and glutathione reductase and their a
Objective:To investigate the association between amplification of the two regulatory genes controlling glutathione(GSH) ......
Malaria is a major cause of morbidity and mortality in the developing world.This situation is mainly due to emergence of......
Roche 公司首次将甲氟喹与中药植物提取物青蒿素的衍生物一起用于临床试验,这种复方制剂对治疗一般恶性疟疾的疗效和耐受力令人满......
青蒿琥酯(artesunate)是青蒿素(artemisinin)的一种衍生物,具有抗疟、抗血吸虫、抗心律失常、免疫调节等功能。青蒿素类化合物对多......
背景:青蒿琥酯具有减轻肺纤维化的作用,但相关机制的研究罕见报道。目的:探讨青蒿琥酯对人胚肺成纤维细胞凋亡的作用及其与Fas,Fas......
青蒿琥酯（artesunate）为一种对恶性疟有快速治疗效果的抗疟药，既能口服、又可经直肠和胃肠外给药，因此，成为治疗严重疟疾，包括脑型疟的理......
目的:研究青蒿琥酯口服对伯氏鼠疟和诺氏猴疟的血液裂殖体杀灭效果。方法:分别在鼠疟和猴疟模型上采用“4-day试验法”、“28-day......
Objective:To evaluate the antimalarial and antiulcerogenic activities ofleaf exlracl and fractions of Melanthera scanden......
Artesunate Effect on Schistosome Thioredoxin Glutathione Reductase and Cytochrome c Peroxidase as Ne
Objective To investigate the possible effect of artesunate(ART) on schistosome thioredoxin glutathione reductase(TGR) an......
目的 观察蒿甲醚对日本血吸虫成虫总抗氧化能力的影响。 方法 体外将血吸虫在含蒿甲醚和氯化血红素的培养液内培养24 h后,或体内感......
Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in r
AIM: To evaluate the effect of artesunate(AS) supplementation on bacterial translocation(BT) and gut microbiota in a rat......
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